It is quite a chore... The problem we had recently when replacing the skin, was that the skin was too small for the Manikin. We tried everything, dish soap, powder, even soaking in really hot water. Nothing worked, finally had to ask Laerdal to send us another one and that one fit. Dish soap does work best when putting on the skins, you can also try placeing skin in really hot water for a while to soften it up and make more pliable (that may help some).